MALARYA

Tanım: Malarya vektörlerle taşınan, Plasmodium vivax, P. ovale ya da P. falciparum türlerinin neden olduğu protozal bir infeksiyondur. infeksiyöz semptomlar, infekte bir sivrisinek tarafından inokülasyon sonrası genellikle 10 gün ila 4 hafta içinde baĢlar. Parazitemi ateş, huzursuzluk, titreme, başağrısı, myalji, bulantı, kusma ve bazı vakalarda anemi, sarılık, hepatosplenomegali ve trombositopeniye sebep olan hemolize ve inflamatuar hücre ve sitokinlerin aktivasyonuna neden olur. 

Gerekçe: şiddetli hastalığı olan hiperparazitemili (örn.:>%10) hastalarda eritrositaferez ya da manüel kırmızı hücre değişiminin kanın akışkanlık özelliğini düzelttiğine (özellikle serebral malaryada) ve parazitten kaynaklanan toksinler, hemolitik metabolitler ve sitokinler gibi patojenik mediatörleri azalttığına inanılmaktadır. 

İşlem: Eritrositaferez 

İşlenen Volüm: 1-2 toplam eritrosit volümü 

Sıklığı: Genellikle 1-2 işlem 

Replasman Sıvısı: Lökositi azaltılmış eritrosit, plazma 

Uygulama sayı ve/veya süresi: Tedavi genellikle <%5 parazitemi sağlanınca sonlandırılır. infeksiyon belirti ve bulgularının devam ettiği yüksek parazit düzeylerinde tedavi sürdürülmelidir. 

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