ANCA İLİŞKİLİ HIZLI İLERLEYEN GLOMERÜLONEFRİT (WEGENER GRANULAMATOZ) 

Tanım: ANCA-ilişkili hızlı ilerleyen glomerulonefrit, hızlı ilerleyen glomerulonefrit nedenlerinden birisidir. Üst ve alt solunum yollarını tutabilen, multisistemik granulomatoz vaskülitle karakterize bir hastalıktır. 

Gerekçe: ANCA antikorlarının varlığı hastalık patogenezinde hümoral komponenti göstermektedir. Dializ bağımlılığı olan veya diffüz alveoler hemorajisi olan hastalarda daha etkindir. 

İşlem:TPD, DFPP, CF, IA 

İşlenen Volüm: 1-1.5 TPH 

Sıklığı: Günaşırı ya da günlük 

Replasman Sıvısı: TDP veya albumin kullanılır. Pulmoner hemorajili hastalarda, plazma dışı replasmana bağlı dilüsyonel koagülopatiden kaçınmak için plazma ile replasman önerilmektedir. 

Uygulama sayı ve/veya süresi: Renal fonksiyonu düzeltme amacı ile kullanılır.Fulminan vakalarda ya da pulmoner hemorajilerdeki günlük uygulamayı takiben her 2-3 günde devam eden toplam 6-9 işlem uygulanabilir. 

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